Michael J. Sweredoski

This study analyzes amino acid substitutions in the SARS-COV-2 spike protein across VOCs, showing increased radical substitutions in key domains like NTD and RBD, and highlights the role of selective pressure in Omicron's evolution.

The paper quantifies MHC Class I peptide origins under UPS perturbation, revealing 30% of peptides are UPS-independent and 10% proteasome-independent, with implications for immune activation.

This study identifies WNK1 as an essential factor for EMC assembly by stabilizing EMC2 and preventing promiscuous interactions.

This paper investigates how SutA, a small protein in Pseudomonas aeruginosa, modulates transcription initiation during growth arrest by interacting with RNA polymerase.

This study identifies Bud13 as an RNA-binding protein that reduces intron retention in Irf7, enhancing type I interferon response and antiviral defense.