A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways
Jennifer L. Mamrosh, David J. Sherman, Joseph R. Cohen, James A. Johnston, Marisa K. Joubert, Jing Li, James Russell Lipford, Brett Lomenick, Annie Moradian, Siddharth Prabhu, Michael J. Sweredoski, Bryan Vander Lugt, Rati Verma, Raymond J. Deshaies
The paper quantifies MHC Class I peptide origins under UPS perturbation, revealing 30% of peptides are UPS-independent and 10% proteasome-independent, with implications for immune activation.
bioRxiv · Oct 7, 2021 · PreprintMolecular Biology