Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
Rebecca S.F. Mok, Wenbo Zhang, Taimoor I. Sheikh, Kartik S. Pradeepan, Isabella Rodrigues Fernandes, Leah C. DeJong, Gabriel Benigno, Matthew R. Hildebrandt, Marat Mufteev, Deivid C. Rodrigues, Wei Wei, Alina Piekna, Jiajie Liu, Alysson Renato Muotri, John B. Vincent, , James Ellis
This study examines the effects of MECP2 mutations on neuronal and network phenotypes in human stem cell-derived excitatory neurons, showing a spectrum of morphological, electrophysiological, and circuitry changes based on mutation severity.
Translational Psychiatry · Oct 17, 2022Peer-reviewedNeuroscience