Author

Isabella Rodrigues Fernandes

University of California San DiegoORCID 0000-0002-8985-4517Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

Alysson Renato MuotriiD· 2 shared Adriano FerrasaiD· 1 shared Alina Piekna· 1 shared Allen Y Wang· 1 shared Alon GoreniD· 1 shared Angels Almenar‐QueraltiD· 1 shared Anju SinghiD· 1 shared Brett TayloriD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Alysson Renato MuotriORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

SETD5 dysfunction in human astrocytes drives IL-6-mediated neuronal impairments via the JAK/STAT signaling pathway

Angels Almenar‐Queralt, Isabella Rodrigues Fernandes, Janaina S de Souza, Anju Singh, Xiwei Shan, Georgia Chaldaiopoulou, Dylan Phan, Kelsey L. Dang, Max W. Chang, Adriano Ferrasa, Noel T Southall, Luisa Bulcao Vieira Coelho, Livia Luz S Nascimento, Brett Taylor, Miguel F. Tenreiro, , Alysson Renato Muotri

This study shows that SETD5 dysfunction in astrocytes increases IL-6, which harms neurons via JAK/STAT signaling, suggesting therapeutic targeting of this pathway for ASD and ID.

bioRxiv · Jul 28, 2026 · PreprintNeuroscience

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations

Rebecca S.F. Mok, Wenbo Zhang, Taimoor I. Sheikh, Kartik S. Pradeepan, Isabella Rodrigues Fernandes, Leah C. DeJong, Gabriel Benigno, Matthew R. Hildebrandt, Marat Mufteev, Deivid C. Rodrigues, Wei Wei, Alina Piekna, Jiajie Liu, Alysson Renato Muotri, John B. Vincent, , James Ellis

This study examines the effects of MECP2 mutations on neuronal and network phenotypes in human stem cell-derived excitatory neurons, showing a spectrum of morphological, electrophysiological, and circuitry changes based on mutation severity.

Translational Psychiatry · Oct 17, 2022Peer-reviewedNeuroscience