Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds
Brian D. Hitt, Ankit Gupta, Ruhar Singh, Ting Yang, Joshua D. Beaver, Ping Shang, Charles L. White, Łukasz A. Joachimiak, Marc I. Diamond
The paper develops anti-tau antibodies that selectively bind pathological tau seeds in neurodegenerative diseases, supporting a model of conformational change at P301.
Journal of Biological Chemistry · Sep 13, 2023Peer-reviewedNeuroscience