Ruhar Singh

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

The paper develops anti-tau antibodies that selectively bind pathological tau seeds in neurodegenerative diseases, supporting a model of conformational change at P301.

The paper standardizes a computational protocol to study pH-dependent protein conformations using simulations and validates it against experimental data on RN80.

The paper analyzes SARS-CoV-2 genome data using multifractal methods to study mutation patterns and host-virus interactions, finding high mutational rates and complex genomic organization.