James Scott

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

This study identifies trimethylamine (TMA) as a microbial compound that inhibits IRAK4, reducing inflammation and improving metabolic outcomes in high-fat diet conditions.

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

This study identifies DNA methylation changes associated with extreme obesity and finds causal effects on obesity and metabolic disturbances using Mendelian Randomisation.

Genetic Association Study of Childhood Aggression across raters, instruments and age

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.