Beaté St Pourcain

Unravelling the genetic basis of stuttering: GWAS meta-analysis highlights link with rare speech disorders

This study conducts a GWAS meta-analysis of stuttering, identifying genetic links with speech disorders and highlighting shared genetic architecture across different ascertainment methods.

Genome-wide analysis of social behaviour in context: a meta-regression approach across social domains, reporters and developmental stages

This study uses genome-wide meta-regression to analyze social behavior across different contexts, ages, and reporters, identifying six genetic loci and showing modest heritability.

Disentangling multivariate relationships between cognition, language and social traits: structures of G, E, and rGE

The paper models shared genomic and environmental influences on cognitive, language, and social traits in children, identifying distinct domains with trait-specific correlations between genetic and environmental factors.

Preschool musicality is associated with school-age communication abilities through genes related to rhythmicity

This study links preschool musicality to school-age communication abilities through genetic factors related to rhythmicity using polygenic scores and structural equation modeling.

Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study.

The paper examines genetic and phenotypic heterogeneity in early neurodevelopmental traits using data from the Norwegian Mother, Father, and Child Cohort Study, identifying 11 latent factors and trait-specific genetic correlations with autism, ADHD, and schizophrenia.

Genome-wide association meta-analysis of age at onset of walking

This paper conducts a genome-wide association meta-analysis of age at onset of walking, identifying 11 loci and showing genetic correlations with ADHD, BMI, intelligence, and brain structure.

Structural models of genome-wide covariance identify multiple common dimensions in autism

The paper uses structural equation modeling to identify three genetic factors linked to language/cognition, behavior, and motor development in ASD, revealing novel associations and simplex-specific genetic overlaps.

Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

The Multivariate Genome-wide Architecture of Interrelated Literacy, Language and Working Memory Skills Reveals Distinct Etiologies

The paper models genetic relationships between literacy, language, and working memory skills in UK youth, identifying shared and distinct genetic factors.

Genetic Association Study of Childhood Aggression across raters, instruments and age

This study conducts a genome-wide association meta-analysis of childhood aggression across multiple raters, instruments, and ages, identifying genetic correlations with various traits but no genome-wide significant SNPs.

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

This paper investigates the genetic architecture of early vocabulary skills and their associations with later-life reading and cognitive abilities using longitudinal data from 6,524 children.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

The amplification of genetic factors for early vocabulary during children's language and literacy development

The paper quantifies genetic amplification and innovation in language development using structural equation models, finding early vocabulary genetics explain significant variation in later cognitive and literacy skills.

Alcohol consumption and mate choice in UK Biobank: comparing observational and Mendelian randomization estimates

This study examines the relationship between alcohol consumption and mate selection using UK Biobank data, finding that genetic variants associated with alcohol use influence partner selection.

Shared risk alleles with discordant polygenic effects: Disentangling the genetic overlap between ASD and ADHD

The paper shows shared genetic risk alleles between ASD and ADHD that have opposite effects on educational attainment, suggesting pleiotropic mechanisms.

Common risk variants identified in autism spectrum disorder

This study identifies five genome-wide significant loci and seven shared with other traits in a large ASD GWAS, highlighting polygenic heterogeneity and the value of large-scale GWAS in ASD.

Genome Wide Association Scan identifies new variants associated with a cognitive predictor of dyslexia.

The paper conducts a GWAS to identify genetic variants associated with a cognitive predictor of dyslexia, finding significant associations with variants near MIR924HG and NKAIN3.

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

The paper investigates polygenic associations between ADHD and literacy/language abilities, finding that genetic confounding with educational attainment masks ADHD-specific reading impairments.

DNA methylation mediates genetic liability to non-syndromic cleft lip/palate

The paper identifies three loci where genetic liability to non-syndromic cleft lip/palate may be mediated by DNA methylation variation in blood and tissue.

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

The paper investigates genetic overlap between non-syndromic cleft lip/palate and facial morphology using polygenic risk scores and Mendelian randomization, finding a causal relationship with philtrum width.

Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals

The paper uses multivariate genetic models to show how genetic influences on social-communication difficulties change over time, with distinct factors at different developmental stages.

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

LD Hub provides a centralized database and web interface for performing LD score regression on GWAS summary data to estimate SNP heritability and genetic correlations across traits.