Preferential Pharmacological Inhibition of Nav1.6, but not Nav1.1, Abolishes Epileptiform Activity Induced by 4-AP in Mouse Cortical Slices
Reesha R. Patel, Xingjie Ping, Shaun R. Patel, Jeff S. McDermott, Jeffrey L. Krajewski, Xian Xuan Chi, Eric S. Nisenbaum, Xiaoming Jin, Theodore Cummins
This study investigates the effects of inhibiting specific voltage-gated sodium channel isoforms on epileptiform activity in mouse cortical slices, finding that Nav1.6 inhibition is more effective than Nav1.1 inhibition.
bioRxiv · May 29, 2020 · PreprintNeuroscience