Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib
Jan Sklenicka, Tung Tran, María Soledad Ramirez, Haley M. Donow, Angel J. Magaña, Travis M. Lavoi, Yasir Mamun, Verónica Jiménez, Prem P. Chapagain, Radleigh G. Santos, Clemencia Pinilla, Marc A. Giulianotti, Marcelo E. Tolmasky
This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.
Antibiotics · Jul 19, 2024Peer-reviewedBiochemistry