Author

Yasir Mamun

Florida International UniversityORCID 0000-0001-6479-6923Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Prem P. ChapagainiD· 3 shared Shomita FerdousiD· 2 shared Yuk‐Ching Tse‐DinhiD· 2 shared Adel NefziiD· 1 shared Angel J. MagañaiD· 1 shared Clemencia PinillaiD· 1 shared Fenfei LengiD· 1 shared Haley M. Donow· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

Prem P. ChapagainORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 5, 2026

Investigation of potential hinge region for Mycobacterium tuberculosis topoisomerase I conformational change during catalysis

Shomita Ferdous, Yasir Mamun, Thirunavukkarasu Annamalai…·Yuk‐Ching Tse‐Dinh

The paper identifies a potential hinge region in MtbTOP1 critical for conformational changes during DNA relaxation, showing that mutations disrupt enzyme activity.

DOI 10.64898/2026.02.04.703551

protein structureexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 18, 2025

Identification of novel human topoisomerase III beta inhibitors

Yasir Mamun, Somaia Haque Chadni, Ramanjaneyulu Rayala…·Yuk‐Ching Tse‐Dinh

The paper identifies potential inhibitors of TOP3B using molecular dynamics and docking, showing that bemcentinib and its analogs inhibit TOP3B relaxation activity.

3 citations

humanmechanistic / dynamical model

𝕏 PostBluesky

BiochemistryAntibioticsPeer-reviewedJul 19, 2024

Structure-activity relationship of pyrrolidine pentamine derivatives as inhibitors of the aminoglycoside 6'-N-acetyltransferase type Ib

Jan Sklenicka, Tung Tran, María Soledad Ramirez…·Marcelo E. Tolmasky

This study identifies pyrrolidine pentamine derivatives as inhibitors of AAC(6')-Ib, showing that structural modifications affect inhibitory activity and that molecular docking correlates with potency.

7 citations

statistical modeldrug response / drug discovery

𝕏 PostBluesky