Zhao Zhang

m6A-Driven Intratumoral Cholesterol Biosynthesis Fuels Castration-Resistant Prostate Cancer Progression

This study identifies a functional cooperation between nuclear pore complexes and m6A signaling that promotes castration-resistant prostate cancer by linking mRNA export to cholesterol biosynthesis and androgen production.

Ablation and Seed-driven Restoration of an Alpha-Satellite Devoid Human Centromere Reveals Size Homeostasis Mechanisms

This study uses a genetically tractable neocentromere system to show that centromere formation involves a seed-driven expansion process and size homeostasis mechanisms.

Protein Phosphatase 2A Orchestrates Mitochondrial Dynamics via MAPK Signaling in heart

This study identifies PP2A's role in regulating mitochondrial dynamics via MAPK signaling in heart failure, showing hyperphosphorylated ERK2 drives fission and contributes to cardiomyopathy.

Yeast DNA Polymerase δ Proofreading Nuclease Suppresses Translesion Synthesis and Facilitates Recombination in DNA Lesion Bypass.

This study shows that DNA polymerase δ proofreading nuclease inhibits translesion synthesis and promotes recombination during DNA lesion bypass.

CELF2 promotes tau exon 10 inclusion via hinge domain-mediated nuclear condensation

This study shows CELF2 regulates Tau exon 10 inclusion via IDR-mediated nuclear condensation with NOVA2 and SFPQ, affecting the 4R:3R ratio in mice.

Hormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions

This study shows that optimal AR NTD multivalent interactions are required for enhancer assembly and transcriptional activity, with excessive condensation impairing function and potentially contributing to disease.