The HMD domain of the PAF complex primes Rad6-Bre1 E3 ligase complexes for H2B ubiquitination
Ammarah Tariq, Shin Ohsawa, Riccardo Zenezini Chiozzi, Panagiotis Patsis, Charlie Williams, Alessandro Stirpe, Thomas Andrew Clarke, Konstantinos Thalassinos, Marc Bühler, Thomas Schalch
The paper identifies how the HMD domain of Prf1 in the PAF1C complex activates HULC for H2B ubiquitination by repositioning its RING domains.
bioRxiv · Mar 2, 2026 · PreprintMolecular Biology