Shin Ohsawa

The paper shows that protein-driven osmotic pressure regulates nuclear size and function, affecting chromatin organization and gene expression in yeast, human, and fly cells.

This study shows that non-coding DNA in yeast affects cell size and fitness by sequestering RNA polymerase, reducing transcript levels and impairing growth.

The paper identifies how the HMD domain of Prf1 in the PAF1C complex activates HULC for H2B ubiquitination by repositioning its RING domains.