Jorge L. Chávez

Highly multiplexed design of an allosteric transcription factor to sense novel ligands

This paper introduces Sensor-seq, a high-throughput platform to design and identify allosteric transcription factor biosensors for non-native ligands, demonstrating utility with novel biosensors for naltrexone and quinine.

Incoherent merger network for robust ratiometricgene expression response

This paper designs an incoherent merger network in E. coli to achieve a ratiometric gene expression response that is linear, tunable, and robust to cellular perturbations.