Kyle K. Nishikawa

This paper introduces Meta-SIFT, a method to discover functional sequence motifs in metagenomes to engineer bacteriophage activity, demonstrating its utility in creating variants with novel host specificity.

This paper introduces Sensor-seq, a high-throughput platform to design and identify allosteric transcription factor biosensors for non-native ligands, demonstrating utility with novel biosensors for naltrexone and quinine.

This study examines T7 bacteriophage and E. coli interactions in microgravity, finding delayed initial phage activity but eventual success with mutations enhancing fitness and revealing differences in mutational preferences.

The paper uses deep mutational scanning to map the functional landscape of the T7 bacteriophage receptor binding domain, identifying host-specific functional residues and tradeoffs between activity and host range.