Sebastian Hiller

This paper introduces a high-throughput assay to identify small molecules that specifically inhibit proteins in their nascent chain form, validated with PF846 and a library of 1,760 compounds.

This paper develops a scalable NMR pipeline to characterize protein structure and dynamics, finding that designed proteins adopt intended folds and exhibit unexpected dynamics not captured by current models.

This study shows chaperones modulate enzyme activity in native states, expanding their role beyond protein folding.

The paper identifies Tmem127 as a regulator of T cell homeostasis by controlling IL-7 receptor surface expression and common gamma chain interactions.

The paper completes the BASEL phage collection by overcoming host limitations to isolate new phages, revealing insights into viral host recognition and bacterial immunity.

This study identifies xenorceptides, a new class of antibiotics that target BamA in Gram-negative bacteria, showing potent activity and limited resistance.

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.

This paper designs stable transmembrane beta-barrel nanopores with tailored sizes and shapes using de novo protein design, achieving conductances ranging from 110 pS to 430 pS.

This study reveals that RNA-bound PGC-1α forms liquid-like nuclear condensates to regulate gene expression and transcriptional networks in response to metabolic stimuli.

The paper reports the crystal structure of GSDMD's C-terminal domain to analyze activation determinants and interactions with the N-terminal domain.