Bastian Molitor

Tandem repeats in methanogenic archaea and their viruses reveal a shared potential for rapid genomic diversification

The paper identifies tandem repeats in methanogenic archaea and their viruses, showing they contribute to genomic diversity and adaptation potential.

A host-directed virulence factor of Clostridium perfringens is modulated by gut commensal strains

The paper investigates how gut commensal strains modulate the growth and virulence of Clostridium perfringens through substrate competition and protein level changes.

Virus {Psi}M2 enters a non-lytic lifecycle alternative to lysogeny during infection of Methanothermobacter marburgensis

This study shows that the virus {Psi}M2 can enter a non-lytic lifecycle alternative to lysogeny in Methanothermobacter marburgensis under suboptimal conditions, with genetic variability in viral populations.

Towards complete carbon utilization: Improved methane yield from formate and hydrogen co-feeding through constitutive formate dehydrogenase-gene expression in Methanothermobacter thermautotrophicus ΔH

This study improves methane yield from formate and hydrogen co-feeding by engineering a methanogen to bypass hydrogen-induced genetic regulation of formate metabolism.

Establishing the fluorescence-activating and absorption-shifting tag as a fluorescent reporter protein in Methanothermobacter thermautotrophicus ΔH

This paper establishes the FAST tag as a fluorescent reporter in Methanothermobacter thermautotrophicus, showing temperature-dependent instability and growth phase-dependent promoter regulation.

Metabolic engineering of Methanothermobacter thermautotrophicus ΔH for recombinant acetoin production

This paper demonstrates the production of acetoin from H2 and CO2 in Methanothermobacter thermautotrophicus using an inducible promoter system, achieving stable acetoin yields in continuous cultivation.

Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model

The deletion of aldehyde:ferredoxin oxidoreductase-encoding genes in Clostridium ljungdahlii results in changes in the product spectrum with various carbon sources

This study deletes AOR genes in C. ljungdahlii and shows changes in ethanol and acetic acid production with different carbon sources.

Reprogramming acetogenic bacteria with CRISPR-targeted base editing via deamination

This paper develops a CRISPR-based base-editing tool for acetogenic bacteria to enable precise single-nucleotide modifications without DNA cleavage, improving gene editing efficiency.