Author

Fiona Whelan

The University of AdelaideORCID 0000-0002-0791-6850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Andras HutvagneriD· 2 shared Dominic ScopellitiiD· 2 shared Paul R. JaschkeiD· 2 shared Alix C. HarlingtoniD· 1 shared George McDonald ChurchiD· 1 shared Ignatius Mayo Aquino Pang· 1 shared Keith Edward ShearwiniD· 1 shared Russel M. VincentiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersSynthetic Biology

Andras HutvagnerORCID

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3 papers

Recent·Most cited

Defining bottlenecks and physiological impact of an orthogonal translation initiation system

Dominic Scopelliti, Russel M. Vincent, Andras Hutvagner, Fiona Whelan, William P. Klare, Ignatius Mayo Aquino Pang, George McDonald Church, Paul R. Jaschke

This study develops an orthogonal translation initiation system using an i-tRNA-AAC mutant and evaluates its physiological impact through fluorescence assays, proteomics, and tRNA sequencing.

bioRxiv · Dec 23, 2025 · PreprintSynthetic Biology

The S-lignin O-demethylase SyoA: Structural insights into a new class of heme peroxygenase enzymes

Alix C. Harlington, Tuhin Das, Keith Edward Shearwin, Stephen G. Bell, Fiona Whelan

This paper characterizes the structure and function of SyoA, a heme peroxygenase enzyme that demethylates S-lignin aromatics via the peroxide shunt pathway, revealing key residues critical for its activity.

Nature Communications · Feb 20, 2025Peer-reviewedBiochemistry

Orthogonal translation initiation using the non-canonical initiator tRNA(AAC) alters protein sequence and stability in vivo

Andras Hutvagner, Dominic Scopelliti, Fiona Whelan, Paul R. Jaschke

This study creates an initiator tRNA with an AAC anticodon to initiate translation from GUU start codons, showing altered protein stability and potential for orthogonal translation.

bioRxiv · May 25, 2021 · PreprintSynthetic Biology