Author

Dominic Scopelliti

Macquarie UniversityORCID 0000-0002-3210-8556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Andras HutvagneriD· 3 shared Paul R. JaschkeiD· 3 shared Fiona WhelaniD· 2 shared George McDonald ChurchiD· 1 shared Ignatius Mayo Aquino Pang· 1 shared Russel M. VincentiD· 1 shared William P. KlareiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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3 shared papersSynthetic Biology

Andras HutvagnerORCID

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3 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintApr 17, 2026

Host background shapes the portability of a non-canonical translation initiation system across Escherichia coli strains

Dominic Scopelliti, Andras Hutvagner, Paul R. Jaschke

The paper evaluates how engineered initiator tRNA anticodon mutants function across different Escherichia coli strains, finding strain-dependent variations in translation initiation efficiency and fitness effects.

DOI 10.64898/2026.04.16.719103

E. coliproteomics

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Synthetic BiologybioRxivPreprintDec 23, 2025

Defining bottlenecks and physiological impact of an orthogonal translation initiation system

Dominic Scopelliti, Russel M. Vincent, Andras Hutvagner…·Paul R. Jaschke

This study develops an orthogonal translation initiation system using an i-tRNA-AAC mutant and evaluates its physiological impact through fluorescence assays, proteomics, and tRNA sequencing.

DOI 10.64898/2025.12.21.695813

proteomicsexperimental assay

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Synthetic BiologybioRxivPreprintMay 25, 2021

Orthogonal translation initiation using the non-canonical initiator tRNA(AAC) alters protein sequence and stability in vivo

Andras Hutvagner, Dominic Scopelliti, Fiona Whelan, Paul R. Jaschke

This study creates an initiator tRNA with an AAC anticodon to initiate translation from GUU start codons, showing altered protein stability and potential for orthogonal translation.

2 citations

E. coliproteomics

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