Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation - 'MR Fish'.
Alasdair Warwick, Aroon Dinesh Hingorani, Anthony P. Khawaja, María Gordillo‐Marañón, Abraham Olvera‐Barrios, Kelsey V. Stuart, Catherine A. Egan, Adnan Tufail, Reecha Sofat, Valerie Kuan, Chris Finan, Amand Floriaan Schmidt
The paper introduces MR-Fish, a method using proteomics and Mendelian randomisation to identify causal relationships between proteins and diseases, finding causal links for several proteins associated with conditions like T2DM and CHD.
medRxiv · Jul 11, 2024 · PreprintGenetic & Genomic Medicine