Author

María Gordillo‐Marañón

University College LondonORCID 0000-0003-2993-6577Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Assay:proteomics· 1

Frequent Co-Authors

Amand Floriaan SchmidtiD· 3 shared Aroon Dinesh HingoraniiD· 3 shared Chris FinaniD· 3 shared Magdalena ZwierzynaiD· 2 shared Reecha SofatiD· 2 shared Sandesh ChopadeiD· 2 shared Abraham Olvera‐BarriosiD· 1 shared Adnan TufailiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenetics

Amand Floriaan SchmidtORCID

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3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJul 11, 2024

Harnessing confounding and genetic pleiotropy to identify causes of disease through proteomics and Mendelian randomisation - 'MR Fish'.

Alasdair Warwick, Aroon Dinesh Hingorani, Anthony P. Khawaja…·Amand Floriaan Schmidt

The paper introduces MR-Fish, a method using proteomics and Mendelian randomisation to identify causal relationships between proteins and diseases, finding causal links for several proteins associated with conditions like T2DM and CHD.

6 citations

humanproteomics

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GeneticsNature CommunicationsPeer-reviewedOct 21, 2021

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

María Gordillo‐Marañón, Magdalena Zwierzyna, Pimphen Charoen…·Chris Finan

The paper uses Mendelian randomization and clinical/biological evidence to prioritize lipid-modifying drug targets for coronary heart disease prevention.

31 citations

humanGWAS summary statistics

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GeneticsbioRxivPreprintSep 25, 2019

Genetic drug target validation using Mendelian randomization

Amand Floriaan Schmidt, Chris Finan, María Gordillo‐Marañón…·Aroon Dinesh Hingorani

This paper introduces a mathematical framework to improve Mendelian randomization analysis for drug targets by addressing horizontal pleiotropy when proteins are the risk factors.

10 citations

humanstatistical model

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