Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase
Tomáš Kouba, T. Kovaĺ, Petra Sudzinová, Jiří Pospíšil, Barbora Brezovská, Jarmila Hnilicová, Hana Šanderová, Martina Janoušková, Michaela Šiková, Petr Halada, Michal Sýkora, Ivan Barvı́k, Jiří Nováček, Mária Trundová, Jarmila Dušková, , Libor Krásný
This study identifies HelD as a nucleic acids-clearing factor for RNA polymerase in Mycobacterium smegmatis, revealing its role in recycling RNA polymerase by preventing non-specific DNA interactions and dissociating elongation complexes.
Nature Communications · Dec 18, 2020Peer-reviewedMolecular Biology