Jiří Nováček

This study characterizes the conformational states of human plasminogen using structural biology techniques, revealing closed and open conformations in recombinant and plasma-derived variants.

This study reveals that SpoIVA forms track-like polymers during bacterial spore development, with dimerization and ATPase activity playing distinct roles in its assembly and function.

This study uses cryo-EM to show how the baseplate of phage 812 undergoes conformational changes that trigger tail contraction during infection of Gram-positive bacteria.

This paper introduces an automated workflow for cryo-volume EM that improves resolution and enables structural analysis of vitrified cells and tissues.

This paper reveals how insulin mimetics stabilize the insulin receptor in a novel apo-state that prevents activation by blocking signal transduction.

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

This study characterizes the structure and replication cycle of EhV-201, a virus infecting the climate-modulating alga Emiliania huxleyi, revealing its unique mechanisms for bypassing host defenses and assembling progeny.

This study identifies the DExD/H helicase domain of Dicer as critical for accurate miRNA biogenesis, showing its role in substrate recognition, cleavage, and strand selection in mammals.

This study identifies HelD as a nucleic acids-clearing factor for RNA polymerase in Mycobacterium smegmatis, revealing its role in recycling RNA polymerase by preventing non-specific DNA interactions and dissociating elongation complexes.