Jan Dohnálek

Light-dependent flavin redox and adduct states control the conformation and DNA binding activity of the transcription factor EL222

This study investigates how light-induced changes in the flavin cofactor of EL222 affect its conformation and DNA binding, revealing two distinct lit states and their role in photoactivation.

Crystal structure of the human NKR-P1 bound to its lymphocyte ligand LLT1 reveals receptor clustering in the immune synapse

The paper solves the crystal structures of NKR-P1 and its complex with LLT1, revealing how clustering enhances inhibitory signaling in the immune synapse.

Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase

This study identifies HelD as a nucleic acids-clearing factor for RNA polymerase in Mycobacterium smegmatis, revealing its role in recycling RNA polymerase by preventing non-specific DNA interactions and dissociating elongation complexes.