The paper identifies a treatment-resistant fibroblast state in RA synovitis that drives chronic inflammation through senescence-associated mechanisms and highlights therapeutic targets beyond cytokine inhibition.

bioRxiv · Jun 29, 2026 · PreprintImmunology

Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathology

Masahiro Nakano, Michihiro Kono, Kenichiro Asahara, Takayuki Katsuyama, Satoshi Kubo, Eri Katsuyama, Yuya Fujita, Takahiro Nishino, Hajime Inokuchi, Takahiro Arakawa, Tsugumi Kawashima, Shohei Noma, Akiko Minowa, Reza Bagherzadeh, Yukiro Matsumoto, , Kazuyoshi Ishigaki

The paper identifies novel cell states and molecular profiles in lupus patients using single-cell data, linking them to disease severity and treatment outcomes.

bioRxiv · Mar 10, 2026 · PreprintImmunology

Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis

Kazuyoshi Ishigaki, Saori Sakaue, Chikashi C. Terao, Yang Luo, Kyuto Sonehara, Kensuke Yamaguchi, Tiffany Amariuta, Chun Lai Too, Vincent A. Laufer, Ian C. Scott, Sébastien Viatte, Meiko Takahashi, Koichiro Ohmura, Akira Murasawa, Motomu Hashimoto, , Soumya Raychaudhuri

This study conducts a trans-ancestry GWAS of rheumatoid arthritis, identifying 124 loci, 34 novel, and shows improved polygenic risk score performance across populations.

medRxiv · Dec 1, 2021 · PreprintGenetic & Genomic Medicine