Passage of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication
Eri Nakayama, Bing Tang, Romal Stewart, Abigail L. Cox, Kexin Yan, Cameron R. Bishop, Troy D. Dumenil, Wilson Nguyen, Andrii Slonchak, Julian D. J. Sng, Alexander A. Khromykh, Viviana P. Lutzky, Daniel J. Rawle, Andreas Suhrbier
This study shows that ZIKV envelope glycosylation mutants V153D and N154D, selected in Rag1-/- mice, replicate more efficiently in vitro and in organoids, suggesting N-linked glycosylation is not essential for envelope folding and trafficking.
Virus Evolution · Jan 1, 2025Peer-reviewedMicrobiology