Wilson Nguyen

Apolipoprotein E governs neuroinflammation resolution and recovery from viral encephalitis

This study identifies Apolipoprotein E as a key driver of neuroinflammation resolution and recovery from viral encephalitis using a mouse model and patient data.

Insect-specific Yada Yada virus chimeric vaccines protect against chikungunya and Ross River virus-induced arthritis

This paper develops insect-specific alphavirus chimeric vaccines for chikungunya and Ross River viruses, showing efficacy in protecting against disease but no cross-protection.

Characterisation and phylogenetic analysis of Murray Valley encephalitis virus (MVEV) from the Ralph Doherty collection.

This study sequences and analyzes MVEV isolates from the Ralph Doherty collection, identifies new genotypes, and establishes mouse models of MVEV disease.

Passage of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication

This study shows that ZIKV envelope glycosylation mutants V153D and N154D, selected in Rag1-/- mice, replicate more efficiently in vitro and in organoids, suggesting N-linked glycosylation is not essential for envelope folding and trafficking.

Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice

This study tracks inflammation resolution in lungs of K18-hACE2 mice infected with SARS-CoV-2 omicron BA.1, showing reduced cytokine signatures and increased anti-inflammatory cell types over time.

TMEM106B-mediated SARS-CoV-2 infection allows for robust ACE2-independent infection in vitro but not in vivo

This study identifies TMEM106B as a key mediator of ACE2-independent SARS-CoV-2 infection in vitro but shows no in vivo neuroinvasiveness or respiratory tract replication in mice.

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.