Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
Umesh Bhattarai, Xiaochen He, Ziru Niu, Lihong Pan, Dongzhi Wang, Hao Wang, Heng Zeng, Jian‐Xiong Chen, Joshua S. Speed, John S. Clemmer, John Edward Hall, Yingjie Chen
This study shows that genetic inhibition of IL-12β reduces cardiac inflammation and heart failure in mice subjected to transverse aortic constriction.
bioRxiv · Sep 5, 2025 · PreprintPhysiology