MMP14 cleaves PTH1R in the chondrocyte derived osteoblast lineage, curbing signaling intensity for proper bone anabolism
Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu, Mingpeng Kong, Zhijia Tan, Kwok Yeung Tsang, Zhongjun Zhou, Kathryn S.E. Cheah
The paper identifies MMP14 as a regulator of PTH signaling in osteoblast lineage cells, showing that MMP14 cleavage of PTH1R reduces signaling intensity, promoting bone anabolism.
eLife · Mar 9, 2023Peer-reviewedDevelopmental Biology