Peikai Chen

The paper identifies MMP14 as a regulator of PTH signaling in osteoblast lineage cells, showing that MMP14 cleavage of PTH1R reduces signaling intensity, promoting bone anabolism.

The paper uses peptide location fingerprinting to identify age- and disease-related structural changes in proteins across species and tissues.

DIPPER provides a spatiotemporal proteomics atlas of human intervertebral discs, revealing region-specific regulatory profiles and a hydration matrisome linked to MRI intensity.

This paper introduces a framework to estimate driver tissues of complex diseases by analyzing selective gene expression from GWAS data, finding lung as a driver tissue for rheumatoid arthritis.