Kathryn S.E. Cheah

The paper identifies MMP14 as a regulator of PTH signaling in osteoblast lineage cells, showing that MMP14 cleavage of PTH1R reduces signaling intensity, promoting bone anabolism.

The paper shows hypertrophic chondrocytes dedifferentiate into marrow-associated stem/progenitor cells that contribute to osteoblasts, adipocytes, and bone marrow establishment during skeletal development.

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

DIPPER provides a spatiotemporal proteomics atlas of human intervertebral discs, revealing region-specific regulatory profiles and a hydration matrisome linked to MRI intensity.

This paper investigates the interaction between Sox2 and Fgf20 in regulating organ of Corti development, showing their spatially-graded roles in specification and differentiation.

The paper uses polygenic scores to show genetic overlaps between lumbar disc degeneration and height, BMI, and BMD in Chinese and Japanese cohorts.