Author

Yihan Wang

The University of Texas Southwestern Medical CenterORCID 0000-0002-0839-0707Unclaimed ORCID profile · follow to get notified of new preprints

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Yihan Wang1 paper

Biology Disciplines

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Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Gary C. HoniD· 3 shared Anjana SundarrajaniD· 2 shared Daniel A. ArmendariziD· 2 shared Huan ZhaoiD· 2 shared Sean C. GoetschiD· 2 shared Shiqi XieiD· 2 shared Sushama SivakumariD· 2 shared Bruce A. PosneriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Gary C. HonORCID

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3 papers

Recent·Most cited

Regulatory network hubs guide dynamic human lineage specification

Chikara Takeuchi, Sushama Sivakumar, Anjana Sundarrajan, Yihan Wang, Sean C. Goetsch, Huan Zhao, Lei Wang, Mpathi Nzima, Minnie Deng, Kartik N Kulkarni, Lin Xu, Jun Wu, Bruce A. Posner, Maria H. Chahrour, W. Lee Kraus, , Gary C. Hon

The paper identifies dynamic regulatory network hubs in human lineage specification using Perturb-Seq and constructs a deep learning model to predict perturbed TFs in patient transcriptomes.

bioRxiv · Jun 15, 2026 · PreprintGenomics

Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon

The paper uses single-cell CRISPRi screens to show variant-associated enhancers regulate cancer genes in breast cancer, revealing network motifs and subtype-specific functions.

Genome biology · Jan 17, 2025Peer-reviewedGenomics

CHD-associated enhancers shape human cardiomyocyte lineage commitment

Daniel A. Armendariz, Sean C. Goetsch, Anjana Sundarrajan, Sushama Sivakumar, Yihan Wang, Shiqi Xie, Nikhil Munshi, Gary C. Hon

The paper identifies enhancers linked to congenital heart defects that, when repressed, impair human cardiomyocyte differentiation.

eLife · Apr 11, 2023Peer-reviewedGenomics