Chikara Takeuchi

This study uses CRISPRi Perturb-seq to analyze 1,408 autism risk genes in human cortical neurons, identifying 215 genes that cause global transcriptomic dysregulation and uncovering shared transcriptional pathways.

This study identifies SPIN1 as a chromatin regulator that selectively represses young transposable elements in mouse embryonic stem cells through histone modification recognition.

The paper identifies dynamic regulatory network hubs in human lineage specification using Perturb-Seq and constructs a deep learning model to predict perturbed TFs in patient transcriptomes.

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

The paper shows how the transposon Springer rewires gene expression and how Flamenco piRNA clusters remodel to allow transposon spread to the germline.

The paper shows Mod(mdg4)-N variants repress HeT-A retrotransposons by blocking subtelomeric enhancers in Drosophila ovarian cells, leading to female sterility.