Daniel A. Armendariz

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

The paper uses single-cell CRISPRi screens to show variant-associated enhancers regulate cancer genes in breast cancer, revealing network motifs and subtype-specific functions.

The paper identifies enhancers linked to congenital heart defects that, when repressed, impair human cardiomyocyte differentiation.

The paper characterizes the heterogeneity of the interstitium during kidney development and identifies distinct cell states and roles for beta-catenin in medullary interstitial cells.

The paper identifies frequent recombination between sgRNA and barcode in single-cell CRISPR assays, reducing signal-to-noise ratio and suggesting improved methods.