Sushama Sivakumar

This study uses CRISPRi Perturb-seq to analyze 1,408 autism risk genes in human cortical neurons, identifying 215 genes that cause global transcriptomic dysregulation and uncovering shared transcriptional pathways.

The paper identifies dynamic regulatory network hubs in human lineage specification using Perturb-Seq and constructs a deep learning model to predict perturbed TFs in patient transcriptomes.

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

The paper identifies enhancers linked to congenital heart defects that, when repressed, impair human cardiomyocyte differentiation.

This study shows TP53 promotes neural lineage commitment in hESCs by regulating ciliogenesis and Shh signaling through BBS9.

This study shows that loss of the lncRNA Norad leads to PUMILIO hyperactivity, causing genomic instability and mitochondrial dysfunction, resulting in premature aging in mice.