Author

Zeynep Betül Erdem

Leiden University Medical CenterORCID 0000-0002-0840-4689Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Inge H. Briaire‐de BruijniD· 2 shared Judith V.M.G. BovéeiD· 2 shared Noel F.C.C. de MirandaiD· 2 shared Ruud van der BreggeniD· 2 shared Siddh van OostiD· 2 shared Alwine B. KruisselbrinkiD· 1 shared Anouk A. KruiswijkiD· 1 shared Bram HeijsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Inge H. Briaire‐de BruijnORCID

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2 papers

Recent·Most cited

Immune infiltration is linked to increased transcriptional activity and distinct metabolic profiles in chordomas

Siddh van Oost, Rick Ursem, Zeynep Betül Erdem, Sara Cardoso, Sanne Venneker, Ruud van der Breggen, Inge H. Briaire‐de Bruijn, Alwine B. Kruisselbrink, Wilco C. Peul, Károly Szuhai, Robert J. P. van der Wal, René J. M. van Zeijl, Bram Heijs, Noel F.C.C. de Miranda, Judith V.M.G. Bovée

This study links immune infiltration in chordomas to increased transcriptional activity and distinct metabolic profiles, but causality remains unclear.

iScience · Apr 9, 2026Peer-reviewedCancer Biology

Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma

Siddh van Oost, Debora M. Meijer, Zeynep Betül Erdem, Marieke E. Ijsselsteijn, Jessica P Roelands, Suk Wai Lam, Melissa Suraya Boejharat, Brendy E.W.M. van den Akker, Ruud van der Breggen, Inge H. Briaire‐de Bruijn, Lukas J.A.C. Hawinkels, Anouk A. Kruiswijk, Manon van der Ploeg, Pauline M. Wijers‐Koster, Rick L. Haas, , Judith V.M.G. Bovée

This study compares immunogenic features between undifferentiated soft tissue sarcoma and myxofibrosarcoma, finding differences in T cell and macrophage infiltration and their prognostic significance.

Cancer Immunology Immunotherapy · Jul 2, 2025Peer-reviewedCancer Biology