Author

Lukas J.A.C. Hawinkels

Leiden University Medical CenterORCID 0000-0002-2274-9325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Nicole DamiD· 2 shared Tom J. HarryvaniD· 2 shared Vera KempiD· 2 shared Anouk A. KruiswijkiD· 1 shared Bernhard SchmiereriD· 1 shared Bram W. van OsiD· 1 shared Brendy E.W.M. van den Akker· 1 shared Casper H.J. van Eijck· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

Nicole DamORCID

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4 papers

Recent·Most cited

Cancer BiologyCancer Treatment and Research CommunicationsPeer-reviewedJan 1, 2026

Bulk RNA sequencing deconvolution of pancreatic ductal adenocarcinoma identifies cancer-associated fibroblast subsets associated with survival and tumor microenvironment composition

Nicole Dam, Mischa F.B. Steketee, Gaby J. Strijk…·Bram W. van Os

The paper uses bulk RNAseq deconvolution to identify CAF subtypes in early onset PDAC and links their abundance to survival and tumor microenvironment composition.

DOI 10.1016/j.ctarc.2026.101490

humanbulk RNA-seq

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Cancer BiologyMolecular Therapy OncologyPeer-reviewedOct 18, 2025

ZEB1, a novel regulator of Junctional Adhesion Molecule A, impacts sensitivity of pancreatic cancer-associated fibroblasts to oncolytic reovirus

Nicole Dam, Tom J. Harryvan, Hao Dang…·Vera Kemp

This study identifies ZEB1 as a regulator of JAM-A expression in pancreatic fibroblasts, showing that ZEB1 inhibition enhances reovirus sensitivity in these cells.

DOI 10.1016/j.omton.2025.201071

humangenetic perturbation / CRISPR

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Cancer BiologyiSciencePeer-reviewedOct 5, 2025

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype

Tom J. Harryvan, Subinuer Abudukelimu, Imke Stouten…·Lukas J.A.C. Hawinkels

11 citations

mousehuman

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Cancer BiologyCancer Immunology ImmunotherapyPeer-reviewedJul 2, 2025

Divergent Therapeutic and Prognostic Impacts of Immunogenic Features in Undifferentiated Soft Tissue Sarcoma and Myxofibrosarcoma

Siddh van Oost, Debora M. Meijer, Zeynep Betül Erdem…·Judith V.M.G. Bovée

This study compares immunogenic features between undifferentiated soft tissue sarcoma and myxofibrosarcoma, finding differences in T cell and macrophage infiltration and their prognostic significance.

7 citationstop 5%

humanbulk RNA-seq

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