The paper introduces a workflow for analyzing post-translational modifications using proteomics data, revealing new oxidative modifications in animal models.

bioRxiv · Jan 20, 2025 · PreprintBioinformatics

Protein aggregation capture assisted profiling of the thiol redox proteome

Ana Martínez‐Val, Samuel Lozano-Juárez, Jorge Lumbreras, Irene Rodríguez, Marinela Couselo‐Seijas, Ana Simón-Chica, Carlos Galán‐Arriola, Rodrigo Fernández, Estefanía Núñez, Inmaculada Jorge, David Filgueiras Rama, Borja Ibáñez, Jesús Vázquez

The paper introduces PACREDOX, a redox proteomics method that improves efficiency and compatibility with DIA, quantifying thousands of proteins and modified peptides in myocardial tissue.

bioRxiv · Dec 21, 2024 · PreprintSystems Biology

iSanXoT: a Standalone Application for the Integrative Analysis of Mass Spectrometry-Based Quantitative Proteomics Data

Jose Manuel Rodríguez, Inmaculada Jorge, Ana Martínez‐Val, Rafael Barrero-Rodríguez, Ricardo Magni, Estefanía Núñez, Andrea Laguillo-Gómez, Cristina A. Devesa, Juan Antonio López, Emilio Camafeita, Jesús Vázquez

iSanXoT provides a standalone tool for integrative analysis of quantitative proteomics data, offering features like error distribution modeling and workflow customization.

Computational and Structural Biotechnology Journal · Dec 26, 2023Peer-reviewedBioinformatics

Ubiquitin ligase LNX1 is a major regulator of glycine recapture by the presynaptic transporter GlyT2

Estefanía Núñez, Esther Arribas-González, Beatriz López‐Corcuera, Carmen Aragón, Jaime de Juan‐Sanz

This study identifies LNX1 as an E3 ubiquitin ligase that regulates GlyT2 ubiquitination, expression, and activity, revealing a novel mechanism for controlling glycinergic neurotransmission.

bioRxiv · Dec 20, 2017 · PreprintNeuroscience