Ana Martínez‐Val

The proteomics and phosphoproteomics landscape of melanoma under T cell attack

This study profiles the proteomics and phosphoproteomics of melanoma cells under T cell attack to identify immune checkpoint targets and therapeutic vulnerabilities.

EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry

EpiFlow quantifies 16 epigenetic markers per cell using spectral flow cytometry, showing broad applicability across species and biological processes.

The Human Cell Line Phosphoproteome Atlas: A Deep Empirical Resource Revealing Kinase Activity Landscapes

The paper presents a comprehensive human phosphoproteome atlas with over 200,000 phosphosites, improving phosphoproteomics speed and accuracy, and identifies kinase activity patterns linked to drug sensitivity.

Integrative multi-layer workflow for quantitative analysis of post-translational modifications

The paper introduces a workflow for analyzing post-translational modifications using proteomics data, revealing new oxidative modifications in animal models.

Protein aggregation capture assisted profiling of the thiol redox proteome

The paper introduces PACREDOX, a redox proteomics method that improves efficiency and compatibility with DIA, quantifying thousands of proteins and modified peptides in myocardial tissue.

Phosphoproteomics highlights complex resource management upon inflammatory stimulation of fibroblasts

This study uses phosphoproteomics to show that inflammatory stimulation of fibroblasts primarily drives resource and stress management rather than specific inflammatory effector functions.

Systematic optimization of automated phosphopeptide enrichment for high-sensitivity phosphoproteomics

The paper optimizes automated phosphopeptide enrichment to improve phosphoproteome coverage and sensitivity in low-input samples using LC-MS/MS.

Deciphering molecular mechanisms of synergistic growth reduction in kinase inhibitor combinations

This study investigates synergistic effects of kinase inhibitor combinations by analyzing phosphoproteomics and transcriptomics data to identify molecular mechanisms and pathway interactions.

iSanXoT: a Standalone Application for the Integrative Analysis of Mass Spectrometry-Based Quantitative Proteomics Data

iSanXoT provides a standalone tool for integrative analysis of quantitative proteomics data, offering features like error distribution modeling and workflow customization.

Hybrid-DIA: Intelligent Data Acquisition for Simultaneous Targeted and Discovery Phosphoproteomics in Single Spheroids

The paper introduces hybrid-DIA, a method combining targeted and discovery phosphoproteomics for single spheroids, showing comparable accuracy to existing methods while profiling the global phosphoproteome.

Narrow-window DIA: Ultra-fast quantitative analysis of comprehensive proteomes with high sequencing depth

The paper introduces Narrow-window DIA, a fast proteomics method enabling high-throughput and comprehensive proteome analysis with high precision and accuracy.

Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution

The paper develops a high-throughput workflow for subcellular proteome and phospho-proteome profiling and applies it to study EGFR signaling and stress responses in cells.