Emilio Camafeita

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

This paper introduces kinetic fingerprints to evaluate KIT inhibitors, showing that residence time and dissociation rates predict clinical success and resistance.

MT4-MMP-mediated NRP1 shedding fine-tunes VEGFA signaling dynamics during embryonic brain angiogenesis

This study identifies MT4-MMP as a regulator of NRP1 shedding, which modulates VEGFA signaling during embryonic brain angiogenesis and wound repair.

EpiFlow: multidimensional single-cell epigenetic profiling by spectral flow cytometry

EpiFlow quantifies 16 epigenetic markers per cell using spectral flow cytometry, showing broad applicability across species and biological processes.

Loss of the alternative calcineurin variant CnAβ1 enhances brown adipocyte differentiation and drives metabolic overactivation through FoxO1 activation

This study shows that loss of CnAβ1 enhances brown adipocyte differentiation and metabolic activity through FoxO1 activation, leading to improved insulin sensitivity and reduced body weight on a high-fat diet.

Integrative multi-layer workflow for quantitative analysis of post-translational modifications

The paper introduces a workflow for analyzing post-translational modifications using proteomics data, revealing new oxidative modifications in animal models.

In-gel protein digestion using acidic methanol produces a highly selective methylation of glutamic 1 acid residues.

The paper shows that in-gel protein digestion with acidic methanol selectively methylates glutamic acid residues, not other methylable residues like aspartic acid.

iSanXoT: a Standalone Application for the Integrative Analysis of Mass Spectrometry-Based Quantitative Proteomics Data

iSanXoT provides a standalone tool for integrative analysis of quantitative proteomics data, offering features like error distribution modeling and workflow customization.

SARS-CoV-2 protein Nsp1 alters actomyosin cytoskeleton and phenocopies arrhythmogenic cardiomyopathy-related PKP2 mutant

The paper shows that SARS-CoV-2 Nsp1 protein mimics the effects of a PKP2 mutant by altering actomyosin cytoskeleton organization, suggesting a potential link between viral infection and ACM-like disease.