Author

Vanessa L.S. LaPointe

Maastricht UniversityORCID 0000-0002-0887-7443Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1 Approach:machine learning (classical)· 1 Assay:organoid / primary culture· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Martijn van GriensveniD· 3 shared Anika SchumacheriD· 2 shared Sofia FalloiD· 2 shared Aurélie CarlieriD· 1 shared Dulce Lima CunhaiD· 1 shared Fiona R. PassanhaiD· 1 shared Huiqing ZhouiD· 1 shared Janou A. Y. RoubroeksiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

Martijn van GriensvenORCID

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Author profile →

4 papers

Recent·Most cited

FGF9 treatment reduces off-target chondrocytes from iPSC-derived kidney organoids

Virginie Joris, Anika Schumacher, Maria Paula Marks, Maria José Eischen-Loges, Sofia Fallo, Martijn van Griensven, Vanessa L.S. LaPointe

This paper shows that extending FGF9 treatment in iPSC-derived kidney organoids reduces off-target cartilage without affecting renal structures.

npj Regenerative Medicine · Aug 30, 2025Peer-reviewedCell Biology

Prediction of Cell States and Key Transcription Factors of the Human Cornea through Integrated Single-Cell Omics Analyses

Julian A. Arts, Sofia Fallo, Melanie S. Florencio, Jos G.A. Smits, Dulce Lima Cunha, Janou A. Y. Roubroeks, Mor M. Dickman, Vanessa L.S. LaPointe, Rosemary Yu, Huiqing Zhou

This paper integrates single-cell RNA-seq data to create a human corneal cell state meta-atlas and develops a machine learning tool to annotate cell states and identify key transcription factors.

PNAS Nexus · Jul 29, 2025Peer-reviewedCell Biology

COMPUTATIONAL EVIDENCE FOR MULTI-LAYER CROSSTALK BETWEEN THE CADHERIN-11 AND PDGFR PATHWAYS

Zeynep Karagöz, Fiona R. Passanha, Lars Robeerst, Martijn van Griensven, Vanessa L.S. LaPointe, Aurélie Carlier

This study uses a computational model to investigate crosstalk between cadherin-11 and PDGFR pathways in hMSCs, revealing an additional layer of crosstalk involving β-catenin and an ERK inhibitor.

Scientific Reports · Sep 22, 2023Peer-reviewedSystems Biology

Structural development of the human fetal kidney: new stages and cellular dynamics in nephrogenesis

Anika Schumacher, Tri Q. Nguyen, Roel Broekhuizen, Martijn van Griensven, Vanessa L.S. LaPointe

This study creates an interactive atlas of human fetal kidney development using electron microscopy, identifying new stages and cellular dynamics in nephrogenesis.

bioRxiv · Mar 24, 2023 · PreprintDevelopmental Biology