This study shows that DM3, an Arabidopsis immune protein, forms dynamic filaments that inactivate its prolyl aminopeptidase activity in response to salt stress.

bioRxiv · Sep 7, 2026 · PreprintPlant Biology

Structure determinants of DANGEROUS MIX 3, an alpha/beta hydrolase, for triggering NLR-mediated genetic incompatibility in plants

Wei-Lin Wan, Gijeong Kim, Nayun Kim, Yi Yun Tan, Machiko Watari, Nuri Charoennit, Rachelle R.Q. Lee, Ignatius Ren Kai Phang, Jinge Wang, Yin Yin Liew, Donghui Hu, Shen Kai Ng, Yizhong Zhang, In‐Cheol Jang, Ji‐Joon Song, Eunyoung Chae

The paper identifies structural determinants of the DM3 alpha/beta hydrolase that trigger NLR-mediated genetic incompatibility in plants by disrupting dimer interface integrity.

Molecular Cell · Jul 1, 2025Peer-reviewedPlant Biology

Transcriptome Reprogramming Associated with Autoimmunity Reveals Key Points of the Growth-Defence Trade-off in Arabidopsis thaliana

Donghui Hu, Jinge Wang, Rachelle R.Q. Lee, Zezhao Su, Wangsheng Zhu, Eunyoung Chae

The paper identifies two major transcriptomic modules representing growth and defence in Arabidopsis thaliana, showing how immune signalling via ADR1s suppresses growth genes to regulate the growth-defence trade-off.

bioRxiv · Jun 30, 2025 · PreprintPlant Biology

Rab2B promotes chaperonin-mediated actin folding and prevents developmental transcription reprogramming and quiescence in trypanosomes

Fengjun Li, Xiaoduo Dong, Yameng Huang, Donghui Hu, Eunyoung Chae, Cynthia Y. He

This study shows Rab2B and actin folding via CCT/TRiC prevent developmental differentiation and quiescence in trypanosomes.

bioRxiv · Nov 27, 2024 · PreprintCell Biology

Generating minimum set of gRNA to cover multiple targets in multiple genomes with MINORg

Rachelle R.Q. Lee, Wei Yuan Cher, Jinge Wang, Yujie Chen, Eunyoung Chae

MINORg generates minimal gRNA sets to cover multiple targets across multiple genomes, reducing workload for pangenomic screens.

Nucleic Acids Research · Feb 24, 2023Peer-reviewedBioinformatics

RPW8/HR Repeats Control NLR Activation in A. thaliana

Ana Cristina Barragan, Rui Wu, Sang‐Tae Kim, Wanyan Xi, Anette Habring, Jörg Hagmann, Anna-Lena Van de Weyer, Maricris Zaidem, William Wing Ho Ho, George Wang, Ilja Bezrukov, Detlef Weigel, Eunyoung Chae

The paper shows that the number of RPW8/HR repeats influences hybrid necrosis severity when combined with specific RPP7 variants in Arabidopsis thaliana.

bioRxiv · Apr 26, 2019 · PreprintGenetics

A rainfall-manipulation experiment with 517 Arabidopsis thaliana accessions

Moises Exposito-Alonso, Rocío Gámez Rodríguez, Cristina Barragán, Giovanna Capovilla, Eunyoung Chae, Jane Devos, Ezgi S. Dogan, Claudia Friedemann, Caspar Gross, Patricia Lang, Derek Lundberg, Vera Middendorf, Jorge Kageyama, Talia Karasov, Sonja Kersten, , Detlef Weigel

The paper presents a rainfall-manipulation experiment with 517 Arabidopsis thaliana accessions to study adaptation and fitness under different climate conditions.

bioRxiv · Jun 8, 2018 · PreprintEvolutionary Biology