Yizhong Zhang

The paper investigates the relationship between fatty acid metabolism and cellular longevity by integrating interactome analyses, transcriptomics, and lifespan assays in human and yeast.

The paper identifies metabolic state transitions regulated by TORC1 that influence cellular aging in yeast and human cells.

This study shows mitochondrial competence determines cellular responses to metabolic interventions during aging, with TORC1 signaling and mitochondrial function being key factors.

The paper identifies structural determinants of the DM3 alpha/beta hydrolase that trigger NLR-mediated genetic incompatibility in plants by disrupting dimer interface integrity.

This study uses RNA-sequencing to analyze how calorie restriction and rapamycin affect gene expression in yeast, revealing their synergistic effect in extending postmitotic cell lifespan.

This study identifies YBR238C as a regulator of cellular aging in yeast, showing it modulates mitochondrial function through HAP4 and RMD9, and links TORC1 activity to mitochondrial feedback loops affecting aging.

This study identifies three distinct pathways by which glucose metabolism activates TORC1 in yeast, including both Rag GTPase-dependent and independent mechanisms.

This study shows curcumin extends the lifespan of aging postmitotic yeast cells with mitochondrial dysfunction, but not under conditions of mitochondrial dysfunction.

This study identifies hemin as an anti-aging agent that extends cellular lifespan through the AMPK pathway and synergizes with rapamycin in human and yeast models.