Independent information from PET, CSF and plasma biomarkers of tau pathology in Alzheimer's disease
Rik Ossenkoppele, Juhan Reimand, Ruben A Smith, Antoine Leuzy, Olof T. Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, the Alzheimer’s Disease Neuroimaging Initiative, Philip Scheltens, Jeffrey L. Dage, Femke H. Bouwman, Kaj Blennow, Niklas Mattsson, Shorena Janelidze, Oskar Hansson
The paper examines the independent associations of PET, CSF, and plasma tau biomarkers with Alzheimer's disease markers, finding that CSF and plasma p-tau181/p-tau217 are more linked to early AD markers, while tau-PET is strongly associated with cognitive and neurodegenerative progression.
EMBO Molecular Medicine · Jul 13, 2021Peer-reviewedNeuroscience