Different functional connectivity gradients reflect aging and Alzheimer's disease
Jonathan Ö. Rittmo, Nicolai Franzmeier, Olof T. Strandberg, Léa Chauveau, Theodore Daniel Satterthwaite, Laura E.M. Wisse, Nicola Spotorno, Hamid Behjat, Amir Dehsarvi, Danielle van Westen, Toomas Erik Anijärv, the Frontotemporal Lobar Degeneration Neuroimaging Initiative, Susan M. Landau, Sebastian Palmqvist, Shorena Janelidze, , Jacob W. Vogel
The paper shows aging and Alzheimer's disease alter distinct functional connectivity axes in the brain, with AD affecting the sensory-association axis and aging affecting the representation-executive axis.
Nature Neuroscience · Oct 1, 2026Peer-reviewedNeuroscience