Sebastian Palmqvist

Different functional connectivity gradients reflect aging and Alzheimer's disease

The paper shows aging and Alzheimer's disease alter distinct functional connectivity axes in the brain, with AD affecting the sensory-association axis and aging affecting the representation-executive axis.

Stable episodic memory and high education do not influence the rate of Alzheimer's disease pathology as measured by plasma p-tau217

The paper examines whether stable episodic memory or high education affects Alzheimer's disease pathology measured by plasma p-tau217, finding no such association.

Dynamical Aβ-Tau-Neurodegeneration Model Predicts Alzheimer's Disease Mechanisms and Biomarker Progression

The paper introduces a dynamical ATN model to simulate and predict the spatiotemporal progression of Aβ, tau, and neurodegeneration in Alzheimer's disease using multimodal imaging data.

Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease

The paper shows that individual functional brain connectivity improves the explanation of tau PET patterns in Alzheimer's disease compared to group-level data.

Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer's Disease

The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease

This study investigates how brain network dynamics and regional vulnerability influence tau propagation and load in Alzheimer's disease using multi-scale simulations.

Multiscale Quantification of Hemispheric Asymmetry in Cortical Maps Using Geometric Eigenmodes

This paper introduces a laterality index to quantify hemispheric asymmetry in cortical maps using geometric eigenmodes, validated on fMRI and tau-PET data from Alzheimer's disease patients.

Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease

The paper compares medial temporal lobe atrophy patterns in early-onset and late-onset amnestic Alzheimer's disease, finding similar atrophy levels but differences in specific subregions.

Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases

The paper identifies reference proteins in cerebrospinal fluid that improve the accuracy and interpretability of biomarkers for brain diseases by accounting for inter-individual variability.

Independent information from PET, CSF and plasma biomarkers of tau pathology in Alzheimer's disease

The paper examines the independent associations of PET, CSF, and plasma tau biomarkers with Alzheimer's disease markers, finding that CSF and plasma p-tau181/p-tau217 are more linked to early AD markers, while tau-PET is strongly associated with cognitive and neurodegenerative progression.

Medial temporal atrophy in preclinical dementia: visual and automated assessment during six year follow-up

The paper assesses longitudinal medial temporal lobe atrophy in preclinical dementia using visual and automated methods over six years, finding that visual ratings correlate with subcortical volumes but have low inter-rater agreement.