Author
Lund UniversityORCID 0000-0002-8885-7724Unclaimed ORCID profile · follow to get notified of new preprints
15 papers
Recent·Most cited
Gabriele Vilkaite, Emma Volcov, Lijun An, Yu Xiao, Inès Hristovska, Camila Rosat Consiglio, Alexa Pichet Binette, Niklas Mattsson, Chris Gaiteri, Jacob W. Vogel
The paper identifies robust multicellular axes associated with Alzheimer's disease pathology and sex using single-cell data from 427 donors, validated in an independent dataset.
bioRxiv · Oct 23, 2026 · PreprintNeuroscience
Jonathan Ö. Rittmo, Nicolai Franzmeier, Olof T. Strandberg, Léa Chauveau, Theodore Daniel Satterthwaite, Laura E.M. Wisse, Nicola Spotorno, Hamid Behjat, Amir Dehsarvi, Danielle van Westen, Toomas Erik Anijärv, the Frontotemporal Lobar Degeneration Neuroimaging Initiative, Susan M. Landau, Sebastian Palmqvist, Shorena Janelidze, , Jacob W. Vogel
The paper shows aging and Alzheimer's disease alter distinct functional connectivity axes in the brain, with AD affecting the sensory-association axis and aging affecting the representation-executive axis.
Nature Neuroscience · Oct 1, 2026Peer-reviewedNeuroscience
Bárbara Avelar‐Pereira, Nicola Spotorno, Anna Orduña Dolado, Divya Bali, Annelie Nordin Adolfsson, Niklas Mattsson, Sebastian Palmqvist, Shorena Janelidze, Oskar Hansson, Lars H Nyberg
The paper examines whether stable episodic memory or high education affects Alzheimer's disease pathology measured by plasma p-tau217, finding no such association.
bioRxiv · Apr 21, 2026 · PreprintNeuroscience
Pavanjit Chaggar, Jacob W. Vogel, Travis Thompson, Roxana Aldea, Olof T. Strandberg, Erik Stomrud, Sebastian Palmqvist, Rik Ossenkoppele, Saâd Jbabdi, Stefano Magon, Gregory Klein, Alzheimer’s Disease Neuroimaging Initiative, Niklas Mattsson, Oskar Hansson, Alain Goriely
The paper introduces a dynamical ATN model to simulate and predict the spatiotemporal progression of Aβ, tau, and neurodegeneration in Alzheimer's disease using multimodal imaging data.
bioRxiv · Jan 29, 2026 · PreprintNeuroscience
Hamid Behjat, Jacob W. Vogel, Olof T. Strandberg, Nicola Spotorno, Nicolai Franzmeier, Léa Chauveau, Jonathan Ö. Rittmo, Sara Stampacchia, Lyduine Eisa Collij, Alexa Pichet Binette, Yu Xiao, Pavan Chaggar, Zeyu Zhu, the Alzheimer's Disease Neuroimaging Initiative, Dimitri Van De Ville, , Rik Ossenkoppele
The paper shows that individual functional brain connectivity improves the explanation of tau PET patterns in Alzheimer's disease compared to group-level data.
bioRxiv · Oct 2, 2025 · PreprintNeuroscience
Toomas Erik Anijärv, Rik Ossenkoppele, Ruben A Smith, Alexa Pichet Binette, Lyduine Eisa Collij, Hamid Behjat, Jonathan Ö. Rittmo, Linda Karlsson, Khazar Ahmadi, Olof T. Strandberg, the Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul S. S Aisen, Ronald Carl Petersen, Clifford R. Jack, , Oskar Hansson
The paper investigates whether hemispheric asymmetry in tau pathology in Alzheimer's disease is linked to reduced inter-hemispheric connectivity or asymmetric amyloid-beta distribution, finding a strong association with amyloid-beta laterality.
Nature Communications · Sep 5, 2025Peer-reviewedNeuroscience
Pavanjit Chaggar, Jacob W. Vogel, Alexa Pichet Binette, Travis Thompson, Olof T. Strandberg, Niklas Mattsson, Linda Karlsson, Erik Stomrud, Saâd Jbabdi, Stefano Magon, Gregory Klein, the Alzheimer’s Disease Neuroimaging Initiative, Oskar Hansson, Alain Goriely
The paper develops a mechanistic model of tau protein dynamics using PET data to predict regional tau accumulation and disease progression stages in Alzheimer's patients.
PLoS Biology · Jul 21, 2025Peer-reviewedNeuroscience
Yu Xiao, Nicola Spotorno, Lijun An, Vincent Bazinet, Justine Y. Hansen, Olof T. Strandberg, Golia Shafiei, Hamid Behjat, Thomas Funck, Gemma Salvadó, Erik Stomrud, Ruben A Smith, Sebastian Palmqvist, Rik Ossenkoppele, Niklas Mattsson, , Jacob W. Vogel
This study investigates how brain network dynamics and regional vulnerability influence tau propagation and load in Alzheimer's disease using multi-scale simulations.
bioRxiv · Apr 17, 2025 · PreprintNeuroscience
Anika Wuestefeld, Alexa Pichet Binette, Danielle van Westen, Olof T. Strandberg, Erik Stomrud, Niklas Mattsson, Shorena Janelidze, Ruben A Smith, Sebastian Palmqvist, Hannah Baumeister, David Berron, Paul A. Yushkevich, Oskar Hansson, Nicola Spotorno, Laura E.M. Wisse
The paper compares medial temporal lobe atrophy patterns in early-onset and late-onset amnestic Alzheimer's disease, finding similar atrophy levels but differences in specific subregions.
Alzheimer s Research & Therapy · Sep 16, 2024Peer-reviewedNeuroscience
Linda Karlsson, Jacob W. Vogel, Ida Arvidsson, Kalle Åström, Shorena Janelidze, Kaj Blennow, Sebastian Palmqvist, Erik Stomrud, Niklas Mattsson, Oskar Hansson
The paper identifies reference proteins in cerebrospinal fluid that improve the accuracy and interpretability of biomarkers for brain diseases by accounting for inter-individual variability.
Nature Communications · May 1, 2024Peer-reviewedNeuroscience
Jing Hua Zhao, David Stacey, Niclas Eriksson, Erin Macdonald-Dunlop, Åsa K. Hedman, Anette Kalnapenkis, Stefan Enroth, Domenico Cozzetto, Jonathan L. Digby-Bell, Jonathan Marten, Lasse Folkersen, Christian Herder, Lina Jönsson, Sarah E. Bergen, Christian Gieger, , James E. Peters
The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.
Nature Immunology · Aug 10, 2023Peer-reviewedGenetic & Genomic Medicine
Erin Macdonald-Dunlop, Lucija Klarić, Lasse Folkersen, Paul R. H. J. Timmers, Stefan Gustafsson, Jing Hua Zhao, Niclas Eriksson, Anne Richmond, Stefan Enroth, Niklas Mattsson, Daria V. Zhernakova, Anette Kalnapenkis, Martin Magnusson, Eleanor Wheeler, Shih‐Jen Hwang, , James F. Wilson
This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.
medRxiv · Aug 3, 2021 · PreprintGenetic & Genomic Medicine
Rik Ossenkoppele, Juhan Reimand, Ruben A Smith, Antoine Leuzy, Olof T. Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, the Alzheimer’s Disease Neuroimaging Initiative, Philip Scheltens, Jeffrey L. Dage, Femke H. Bouwman, Kaj Blennow, Niklas Mattsson, Shorena Janelidze, Oskar Hansson
The paper examines the independent associations of PET, CSF, and plasma tau biomarkers with Alzheimer's disease markers, finding that CSF and plasma p-tau181/p-tau217 are more linked to early AD markers, while tau-PET is strongly associated with cognitive and neurodegenerative progression.
EMBO Molecular Medicine · Jul 13, 2021Peer-reviewedNeuroscience
Philip S. Insel, Michael Donohue, David Berron, Oskar Hansson, Niklas Mattsson
The paper estimates the time-course of pathological markers and cognitive dysfunction in Alzheimer's disease relative to Aβ-positivity, finding tau and cognitive changes occur years before significant Aβ accumulation.
NeuroImage · Dec 24, 2020Peer-reviewedNeuroscience
Jacob W. Vogel, Niklas Mattsson, Yasser Iturria‐Medina, Olof T. Strandberg, Michael Schöll, Christian L. Dansereau, Sylvia Villeneuve, Wiesje M. van der Flier, Philip Scheltens, Pierre Bellec, Alan Charles Evans, Oskar Hansson, Rik Ossenkoppele, The Alzheimer's Disease Neuroimaging Initiative, The Swedish BioFINDER Study
This study uses data-driven clustering to identify spatial patterns of tau-PET distribution in Alzheimer’s disease and compares them to pathology-driven ROIs, finding two clusters with strong cognitive associations.
Human Brain Mapping · Oct 19, 2018Peer-reviewedNeuroscience