Charlotte Elisabeth Teunissen

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants.

The paper measures soluble SORL1 (sSORL1) in CSF to assess functional impact of rare SORL1 variants, finding lower sSORL1 in carriers of pathogenic variants.

Data-driven evaluation of suitable immunogens for improved antibody selection

This study evaluates immunogen properties to improve antibody selection by analyzing structural and functional features and developing a tool for applying these insights.

TREM2 Risk Variants with Alzheimer Disease Differ in Rate of Cognitive Decline

This study examines whether TREM2 risk variants in Alzheimer's disease patients lead to distinct clinical phenotypes, finding no baseline differences but faster cognitive decline in carriers.

Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes

This study maps quantitative trait loci for CSF metabolites and identifies associations with brain traits, revealing potential neurobiological pathways.

Blood-based multivariate methylation risk score for cognitive impairment and dementia

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

Proteome encoded determinants of protein sorting into extracellular vesicles

This study predicts protein association with extracellular vesicles using sequence-based models and identifies palmitoylation as a key determinant.

In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer's Disease

This study shows that SORL1 haploinsufficiency in pigs mimics early AD biomarker changes without neurodegeneration, supporting its role as a causal gene in Alzheimer's disease.

Testing the link between isoaspartate and Alzheimer's disease etiology

The paper investigates the link between isoaspartate (isoAsp) and Alzheimer's disease by analyzing isoAsp levels and related biomarkers in blood samples from AD patients and healthy controls.

Genome-wide association study of Alzheimer's disease brain imaging biomarkers and neuropsychological phenotypes in the EMIF-AD Multimodal Biomarker Discovery dataset

This study performs GWAS on quantitative AD biomarkers and cognitive traits, identifying new loci associated with memory performance and cognitive decline.

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

The paper conducts GWAS on CSF Alzheimer's disease biomarkers, identifying genetic associations with NF-L, YKL-40, and Ng levels.

Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

The paper conducts a genome-wide association study (GWAS) on Alzheimer’s disease CSF biomarkers in the EMIF-AD dataset, identifying novel genetic signals and confirming existing associations.

PET and CSF amyloid-β status are differently predicted by patient features: Information from discordant cases

The paper finds that patient features differentially predict amyloid-β status based on PET or CSF, with variations by disease stage, suggesting PET and CSF discordance provides unique information.

Low frequency and rare coding variation contributes to multiple sclerosis risk

The paper identifies low-frequency coding variants contributing to multiple sclerosis risk using a large case-control study.

Cellular phenotyping of hippocampal progenitors exposed to patient serum predicts conversion to Alzheimer’s Disease

This study shows that serum from MCI patients predicts AD conversion up to 3.5 years before diagnosis by altering hippocampal progenitor cell behavior.