Cristiana Valle

This study shows that nuclear DNA damage directly causes mitochondrial dysfunction in C9ORF72 ALS/FTD by triggering a DNA damage response that depletes NAD+ and impairs mitochondrial bioenergetics.

The paper investigates changes in brown adipose tissue and its extracellular vesicles in an ALS mouse model, showing their impact on myoblast homeostasis and muscle atrophy.

This study investigates altered glucose-fatty acid flux in ALS using mouse models and patient-derived myotubes, finding increased fatty acid oxidation linked to slower disease progression but with metabolic heterogeneity across patients.